Takeda Pharmaceutical Company Limited (TSE: 4502) (“Takeda”) today announced new real world data evaluating the comparative effectiveness of Entyvio (vedolizumab) and tumor necrosis factor alpha (TNF) antagonist therapy in patients with moderately to severely active ulcerative colitis (UC) or Crohn’s disease (CD). These data were presented as oral presentations at the 13th Congress of the European Crohn’s and Colitis Organization (ECCO) from February 14 to 17, 2018 in Vienna, Austria. These analyses observed that patients with UC treated with Entyvio compared to TNF antagonist therapy had statistically significant higher 12 month cumulative rates of mucosal healing (50% vs 42%, hazard ratio [HR] 1.73, 95% confidence interval [CI] 1.10 2.73) and clinical remission (54% vs 37%; HR 1.54, 95% CI 1.08 2.18), and numerically higher steroid free clinical remission rates (49% vs 38%; HR 1.43, 95% CI 0.79 2.60).
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